My friend John Taylor mentioned this radio station and, frankly, I'm in love...
Click on the 'listen' tab near the top on the right and you will download a radio file for your iTunes that you can play at anytime from your playlist.
They play a good mix of music, mostly non-mainstream, but always interesting. They don't delve too far into heavy rock, dreary music, noise rock, punk, rap. Basically put, it just plays middle of the road, non-pop radio, quality music; the best parts of every genre. If you dig a little further, I think you can also find their playlists, which is good incase you hear a song you want to hear again and again.
Hope you also enjoy it.